Controlled Cellular Delivery of Amphiphilic Cargo by Redox‐Responsive Nanocontainers

Bioresponsive Controlled Release of Cargo with Glucometer Readout from Mesoporous Silica Nanocontainers for Sensing Non-Glucose Targets

Supramolecular design of biocompatible nanocontainers based on amphiphilic derivatives of a natural compound isosteviol.

Two diterpenoid surfactants with ammonium head groups and bromide (S1) or tosylate (S2) counterions have been synthesized. Exploration of these biomimetic species made it possible to demonstrate that even minor structural changes beyond their chemical nature may dramatically affect their solution behavior. While their aggregation thresholds differ inconsiderably, morphological behavior and affi...

Controlled Dispersion of Carbon Nanotubes by Amphiphilic Polyelectrolytes

Institute of Chemical Engineering and High Temperature Chemical Processes, Foundation for Research and Technology, GR-26504, Patras, Greece J. Heyrovsky Institute of Physical Chemistry, v.v.i., Academy of Sciences of the Czech Republic, CZ-18223, Prague 8, Czech Republic Polymer Institute, Slovak Academy of Sciences, SK-84236 Bratislava, Slovakia Materials Science Department, University of Patr...

The delivery of endocytosed cargo to lysosomes.

In mammalian cells, endocytosed cargo that is internalized through clathrin-coated pits/vesicles passes through early endosomes and then to late endosomes, before delivery to lysosomes for degradation by proteases. Late endosomes are MVBs (multivesicular bodies) with ubiquitinated membrane proteins destined for lysosomal degradation being sorted into their luminal vesicles by the ESCRT (endosom...

Electrically controlled delivery of cargo into single human neural stem cell.

Nanoprobe-based techniques have emerged as an efficient tool for the manipulation and analysis of single cells. Here, we report a powerful whole-electrical single-cell manipulation tool that enables rapid and controllable delivery of cargo into single neural stem cells with precision monitoring of the cell penetration process using a conductive nanoprobe. The highly electrically sensitive nanop...